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Explore the complexities of GLP-1 impurity detection using HPLC/UHPLC and innovative strategies to enhance analysis and regulatory compliance.

Researchers focused on the early stages of developing innovative plant-based active ingredients for skincare, using HPLC to determine which species should be shortlisted for phytochemical profiling.


Giulia Mazzoccanti spoke to LCGC International about the development and application of electrostatic repulsion-reversed phase (ERRP) chromatography for peptide separations.

Metabolomic profiling and the identification of metabolomic markers following HPAI H5N1 infection in chicken was performed in an Indian research study, with metabolite extracts analyzed using LC-MS/MS.

Torgny Fornstedt, Jörgen Samuelsson, and Martin Enmark discuss a novel machine learning workflow for oligonucleotide analysis that is helping to enhance method development and impurity profiling efficiency.

Analyzing Small RNA-based Therapeutics and Their Process Impurities Using Fast and Sensitive LC–HRMS
Discover innovative LC–HRMS methods for analyzing RNA-based therapeutics, enhancing biopharma development and regulatory compliance in drug characterization.

Static and dynamic electrostatic repulsion-reversed phase (ERRP) has been compared for the separation of peptide impurities.

Researchers evaluated the antidiabetic potential of peanut oil, known for its high phytochemical content and medicinal properties, using GC-MS to collect and classify fatty acid compounds within the oil.

This episode of Behind the Peaks focuses on the importance of sound statistical practices in chromatographic analysis.

The advancements in HILIC–MS for oligonucleotide analysis are discussed, highlighting its potential as a viable alternative to traditional methods.

The second part of our interview with Annika van der Zon and Andrea Gargano regarding their research developing poly(acrylamide-co-N,N-methylene-bis(acrylamide) monolithic hydrophilic interaction chromatography columns optimized for protein separation.

Master LC troubleshooting techniques to optimize your analysis and resolve issues with confidence.

Researchers assessed ivermectin (IVM) residues in intensive swine farms—from animal treatment to slurry, soil, and wastewater—to evaluate potential environmental contamination. IVM concentrations were quantified using LC–MS/MS.

In a study conducted at the van 't Hoff Institute for Molecular Sciences at the University of Amsterdam (the Netherlands), researchers developed poly(acrylamide-co-N,N-methylene-bis(acrylamide) monolithic HILIC columns optimized for protein separation.LCGC International spoke to Annika van der Zon and Andrea Gargano, both from the van 't Hoff Institute and corresponding authors of the paper, to learn more about their research



















