A pilot study investigating whether nicotinamide adenine dinucleotide kinase (NADK) expression is selectively diminished in alcohol-associated liver cirrhosis (AC), as well as evaluating its potential as a biomarker for this condition, measured AC and non-AC (NAC). Nicotinamide adenine dinucleotide (NAD+) and nicotinamide adenine dinucleotide phosphate (NADP+) levels in human liver samples were measured using liquid chromatography-mass spectrometry (LC-MS).

Ion mobility spectrometers can detect trace compounds quickly, though they can face various issues with detecting certain peaks. University of Hannover scientists created a new system for resolving hyper-fast gas chromatography (GC) peaks.

Bacteriophages are vital for addressing antibiotic-resistant bacteria, though phage therapies are currently rare. University of Lisbon researchers recently created a new purification workflow to address these concerns.

A joint study between the University of Oklahoma Health Sciences Center (Oklahoma City, Oklahoma) and the UC Davis West Coast Metabolomics Center (Davis, California) identified differentially regulated lipids in type 2 diabetes (T2D) and obesity through the application of reversed-phase liquid chromatography-accurate mass tandem mass spectrometry (RP-LC-accurate MS/MS).

LCGC EAB member Paul Ferguson has been named a professor by special appointment at the Faculty of Science at the University of Amsterdam.

Many multi-column gas chromatography systems use two-position multi-port switching valves, which can suffer from delays in valve switching. Shimadzu researchers aimed to create a new sampling and switching module for these systems.

Polyamides can be difficult to characterize, despite their use in various aspects of everyday life. Vrije Universiteit Amsterdam researchers hoped to address this using a reversed-phase liquid chromatography (RPLC)-based approach.

Saba Aslani from the University of Texas at Arlington spoke to LCGC International about a collaborative project with Northwestern University, the University of Hong Kong, and BioTools, Inc., investigating mirror-image cyclodextrins using ultra-high performance liquid chromatography–tandem mass spectrometry (UHPLC–MS/MS) and vibrational circular dichroism (VCD).

As the push for green chemistry continues to grow, University of Almeria researchers created a review for ways chromatographic techniques could be more environmentally friendly.

In the final section of our interview with Vilmos Kertesz of Oak Ridge National Laboratory, he imparts the most important lessons he would like future generations of scientists to learn.

Separating stereoisomers is an extensively researched and challenging process, with approved substances being rare. A new SFC-based system was made to possibly ease some aspects of these procedures.

Fabrice Gritti, consultant scientist at Waters Corporation, spoke to LCGC International about the history of slalom chromatography (SC) and why he decided that the technique was worth re-investigating. The potential benefits of SC, according to Gritti, include identifying RNA impurities when manufacturing mRNA therapeutics, and assisting in the development of new gene and cell therapies, and other biopharmaceutical applications.

In this month's edition of The LCGC Blog, Andre Striegel discusses where macromolecular scientists around the world can convene and share their insights.

In the penultimate section of our interview with Vilmos Kertesz of Oak Ridge National Laboratory, he reflects on the people who guided him throughout his scientific career.

In the third part of our interview with Vilmos Kertesz of Oak Ridge National Laboratory, he discusses his time creating new liquid extractions and his feelings on seeing his work used around the world.